Natural Botanical
10g Bag
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Natural Botanical Anti-Aging Muscle Relaxant

Buzz Button Powder

Spilanthes Acmella · Acmella Oleracea Extract

Pure Spilanthes Acmella (Acmella Oleracea) extract — nature's most powerful topical muscle relaxant. Rich in spilanthol, a clinically-studied natural alkylamide that relaxes facial muscles, smooths expression lines, and stimulates collagen production. The botanical BOTOX alternative for DIY skincare formulators.

$12.99 / 10g bag

✓ Free shipping on all U.S. orders

Active Compound Spilanthol (N-isobutyl-2,6,8-decatrienamide)
Botanical Source Spilanthes Acmella / Acmella Oleracea
Common Names Buzz Button, Toothache Plant, Paracress, Jambu
Form Fine powder extract
Net Weight 10 grams
Recommended Use 1–3% concentration in serums, creams, or carrier oils
Shelf Life 24 months (stored cool, dry, sealed)
Try Our Ready-Made Serum
🔬 Clinically-Studied Compound
🌿 100% Natural Botanical
📦 Ships Within 24 Hours
🛡️ Satisfaction Guaranteed
Why Buzz Button

Key Benefits of Spilanthes Acmella

Clinically-studied botanical compounds that deliver real, visible anti-aging results.

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Natural Muscle Relaxant

Spilanthol acts as a natural neuromodulator, relaxing subcutaneous facial muscles that cause dynamic wrinkles and expression lines — the same mechanism as BOTOX, but entirely non-invasive and botanical.

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Collagen Stimulation

Stimulates and reorganizes the collagen network, improving skin structure, density, and elasticity. Promotes the natural repair of aged and sun-damaged skin from within.

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Deep Hydration

Increases natural hyaluronic acid production within the dermis. Enhances moisture retention for plumper, softer skin that resists fine line formation from dehydration.

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Anti-Inflammatory

Spilanthol inhibits COX and LOX inflammatory pathways. Reduces redness, calms irritation, and soothes reactive skin — making it safe for even sensitive skin types.

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Antioxidant Defense

Rich in polyphenols, flavonoids, and terpenoids that neutralize free radicals. Protects skin from UV photodamage and environmental stressors that accelerate aging.

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100% Natural & Non-Invasive

No needles. No synthetic toxins. No downtime. A time-honored botanical extract — used for centuries in traditional South American medicine — now validated by modern clinical science.

The Research

How Buzz Button Works

Peer-reviewed science behind Spilanthes Acmella and its active compound spilanthol.

Spilanthol: The Active Compound

Spilanthol (N-isobutyl-2,6,8-decatrienamide) is the primary bioactive alkylamide isolated from Spilanthes Acmella. Its molecular formula is C₁₄H₂₃NO. This lipophilic compound is responsible for the plant's characteristic numbing and muscle-relaxing effects, making it a potent topical anti-wrinkle agent.

Spilanthol works as a natural neuromodulator — it rapidly and progressively inhibits repeated contractions of facial expression muscles, achieving a BOTOX-like effect through an entirely topical, non-invasive mechanism.

Mechanism of Action

When applied topically, spilanthol penetrates the epidermis and acts on subcutaneous muscle fibers. The compound modulates neuromuscular signaling at the dermal level, achieving three key outcomes:

  • Muscle Relaxation: Reduces the intensity and frequency of repetitive facial muscle contractions that form expression lines
  • Collagen Remodeling: Stimulates fibroblast activity to reorganize and strengthen the collagen network
  • Anti-Inflammatory Action: Dual inhibition of COX-2 and LOX pathways via structural similarity to arachidonic acid, reducing NF-κB-mediated inflammation

Clinical Evidence

Published research supports the anti-aging efficacy of Acmella Oleracea extract:

  • An in vivo study demonstrated significant wrinkle depth reduction after just 2 weeks of consistent application (Savic et al., International Journal of Cosmetic Science, 2021)
  • Spilanthol confirmed as a rapid-acting topical muscle relaxant that progressively inhibits facial muscle contractions (Demarne & Passaro, US Patent 2009)
  • Extract shown to stimulate, reorganize and strengthen the collagen network for anti-aging applications (Prachayasittikul et al., 2009)
  • Clinical studies on women aged 20–45 demonstrated improved skin firmness, reduced fine wrinkles, and diminished dark circles over 6 weeks
  • Demonstrated antioxidant vasorelaxation properties and strong free-radical scavenging activity (Wu et al., 2008)

Additional Bioactive Compounds

Beyond spilanthol, Spilanthes Acmella extract contains a rich profile of beneficial compounds that contribute to its anti-aging properties:

  • Triterpenes & Sterols: Support skin barrier function and cellular repair
  • Polyphenols & Flavonoids: Potent antioxidants that neutralize oxidative stress
  • Coumarins: Anti-inflammatory compounds with photoprotective properties
  • Terpenoids: Support wound healing and collagen synthesis
  • Ferulic Acid (trans-ferulic & trans-isoferulic): UV-protective antioxidants that enhance overall formulation stability
Application Guide

How to Use Buzz Button Powder

Simple formulation guide for DIY skincare enthusiasts.

01

Choose Your Base

Select a serum, cream, lotion, or carrier oil as your base. Lightweight serums (water-based or hyaluronic acid serums) work exceptionally well. Our Buzz Button Serum uses a multi-peptide base for maximum synergy.

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Measure & Mix

Add Buzz Button powder at 1–3% concentration. For a 10ml serum, use 0.1–0.3g of powder. Start at 1% for sensitive skin and work up. Stir or shake thoroughly until fully dissolved.

03

Apply Daily

Apply to clean, dry skin focusing on expression lines — forehead, crow's feet, smile lines. Use morning and/or evening. Follow with moisturizer. Allow 2–4 weeks for initial visible results.

04

Stack for Maximum Results

Combine with Snap-8 peptide for dual-mechanism wrinkle reduction. Add GHK-Cu or AHK-Cu copper peptides for collagen stimulation. Layer with hyaluronic acid for enhanced hydration and delivery.

05

Storage

Store sealed in a cool, dry place away from direct sunlight. Keep below 25°C / 77°F. Shelf life is 24 months from date of purchase when stored properly. Finished formulations should be used within 3 months.

06

Patch Test

Always perform a patch test before first use. Apply a small amount to the inside of your wrist or behind your ear. Wait 24 hours. Discontinue if irritation occurs. Buzz Button is generally well-tolerated, including on sensitive skin.

Knowledge Base

Frequently Asked Questions

Everything you need to know about Buzz Button powder.

What is Buzz Button powder?
Buzz Button powder is a pure extract from Spilanthes Acmella (Acmella Oleracea), a flowering plant native to South America also known as the "toothache plant" or "paracress." It contains spilanthol, a natural alkylamide compound with clinically-studied muscle-relaxing properties that smooth expression lines and wrinkles when applied topically. It's widely recognized as nature's BOTOX alternative.
How does Buzz Button powder work for anti-aging?
The active compound spilanthol acts as a natural neuromodulator, relaxing subcutaneous facial muscles that cause expression lines and dynamic wrinkles. It also stimulates collagen production, provides antioxidant protection against free radicals and UV damage, reduces inflammation via COX/LOX inhibition, and increases natural hyaluronic acid levels in the skin for improved hydration.
How do I use Buzz Button powder in my skincare?
Add 1–3% Buzz Button powder to serums, creams, or carrier oils. A typical formulation uses 0.1–0.3g per 10ml of base product. Mix thoroughly until fully dissolved. Apply to clean skin focusing on expression lines (forehead, crow's feet, smile lines) once or twice daily. Can be combined with other peptides like Snap-8, hyaluronic acid, or copper peptides for synergistic anti-aging results.
Is Buzz Button powder safe for sensitive skin?
Yes — Spilanthes Acmella extract is generally well-tolerated across all skin types including sensitive and reactive skin. It actually has documented anti-inflammatory properties (COX-2 and LOX inhibition) that help calm irritation. Always perform a patch test before first full-face use. Start with a lower concentration of 1% and increase gradually as your skin adjusts.
How long before I see results?
Clinical studies show visible smoothing effects can occur within 2 weeks of consistent daily application. Significant wrinkle depth reduction is typically observed at 4–6 weeks, with optimal results at 8 weeks of regular use. Results are cumulative — continued use delivers continued improvement. For faster results, combine with Snap-8 peptide and copper peptides.
What's the difference between the powder and the Buzz Button Serum?
The Buzz Button Powder (this product) is the raw botanical extract in a 10g bag — designed for DIY skincare formulators who want to create their own custom serums, creams, and treatments at their preferred concentration. The Buzz Button Anti-Aging Serum is a ready-to-use 1 oz professional formula that combines 2% Buzz Button extract with a multi-peptide base for synergistic anti-aging — simply apply directly to skin with no mixing required.
Can I combine Buzz Button with Snap-8 or copper peptides?
Absolutely — and we recommend it. Buzz Button (botanical muscle relaxant) + Snap-8 (synthetic SNARE inhibitor) creates a dual-mechanism approach to wrinkle reduction that outperforms either ingredient alone. Adding GHK-Cu or AHK-Cu copper peptides introduces a third mechanism — collagen stimulation — for comprehensive anti-aging. This is the TopicalNotox stack approach.
How should I store Buzz Button powder?
Store sealed in a cool, dry place away from direct sunlight, ideally below 25°C (77°F). Keep the bag tightly sealed when not in use. Shelf life is 24 months from date of purchase when stored properly. Once mixed into a formulation, use within 3 months for best potency.
Complete Your Routine

Pairs Well With

Build the ultimate TopicalNotox anti-aging stack.

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Buzz Button Anti-Aging Serum

Ready-to-use multi-peptide serum with 2% Buzz Button extract. 1 oz bottle.

$39.99
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Snap-8 Peptide Powder

Pure Acetyl Octapeptide-3. The gold standard SNARE inhibitor. 1g.

$100
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GHK-Cu Copper Peptide

Pharmaceutical-grade copper peptide. 300% collagen stimulation. Per gram.

$20/g
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AHK-Cu Enhanced Peptide

Next-gen copper peptide. 40–50% more potent than GHK-Cu. Per gram.

$30/g

Ready to Try Nature's BOTOX Alternative?

Pure Spilanthes Acmella extract. 10g of clinically-studied, botanical anti-aging power. Free shipping on all U.S. orders.