The most advanced non-invasive anti-aging technology. Premium peptides — Snap-8, Buzz Button extract & copper complexes — meet next-generation formulation science. Clinically-proven results without the needles.
Next-generation peptide and botanical skincare. Pharmaceutical-grade ingredients. Real results.
100% pure Acetyl Octapeptide-3. The gold standard in topical wrinkle-reducing peptides. Formulate your own professional-grade anti-aging serums and treatments at home.
Active: Acetyl Octapeptide-3
CAS #: 868844-74-0
Quantity: 1g Premium Powder
Pure Spilanthes Acmella (Acmella Oleracea) extract — nature's muscle relaxant. Contains spilanthol, a natural compound that reduces facial tension and smooths expression lines. The botanical BOTOX alternative.
Active: Spilanthol (Spilanthes Acmella)
Source: Acmella Oleracea Extract
Quantity: 10g Bag
Professional multi-peptide anti-aging serum enhanced with 2% Buzz Button extract. Features a synergistic peptide-rich base for maximum wrinkle reduction, improved elasticity, and deep hydration. 1 oz luxury bottle.
Key Actives: Multi-Peptide + 2% Buzz Button
Volume: 1 oz (30ml) Bottle
Shipping: FREE
Pharmaceutical-grade GHK-Copper complex for maximum collagen production. Up to 300% collagen stimulation. Formulate your own advanced copper peptide serums and treatments.
Active: GHK-Copper Complex
Purity: ≥98% Pharmaceutical Grade
Quantity: Per Gram
Next-generation copper peptide analog with superior potency. 40–50% more collagen stimulation than GHK-Cu. Faster absorption, better penetration, premium pharmaceutical quality.
Active: AHK-Copper Complex
Purity: ≥98% Pharmaceutical Grade
Quantity: Per Gram
Science-backed, non-invasive, and designed for real results.
Peer-reviewed research backing every product. Snap-8 and Spilanthol mechanisms verified in independent studies. No pseudoscience — only evidence-based results.
No injections. No downtime. No toxins. Apply topically and let the peptides and botanicals work. The modern approach to anti-aging.
Up to 30% wrinkle reduction documented in clinical trials. Results visible in 4–8 weeks with consistent use. Real science, real outcomes.
Buzz Button (Spilanthes Acmella) combines ancient botanical wisdom with modern peptide technology. Natural spilanthol works alongside synthetic peptides for synergistic anti-aging.
Pharmaceutical-grade ingredients. Rigorous quality control. Professional formulations. Luxury skincare at accessible pricing — no clinic markups.
BOTOX is being revived — without the needles. Non-invasive peptide and botanical skincare is the future. TopicalNotox leads that future.
Evidence-based formulations powered by peer-reviewed research.
Snap-8 (Acetyl Octapeptide-3) is a synthetic peptide that mimics SNARE proteins without neurotoxicity. It inhibits the formation of the SNARE complex, reducing the muscle contractions that cause dynamic wrinkles — particularly around the forehead and eyes. Unlike botulinum toxin, this mechanism is completely reversible, safer, and non-invasive.
Spilanthes Acmella (Acmella Oleracea), commonly known as the "Buzz Button" or "toothache plant," contains spilanthol — a natural alkylamide compound with clinically-documented muscle-relaxing properties. When applied topically, spilanthol acts on subcutaneous muscle contractions, smoothing expression lines through a completely natural botanical mechanism.
Studies demonstrate visible wrinkle depth reduction comparable to synthetic peptides, with the added benefit of anti-inflammatory and antioxidant properties inherent in the botanical extract.
Multiple peer-reviewed studies demonstrate:
GHK-Cu: The gold-standard copper peptide complex. Stimulates collagen synthesis, promotes wound healing, and improves skin density. Up to 300% collagen stimulation documented in studies.
AHK-Cu: Next-generation copper peptide analog with 40–50% greater collagen stimulation than GHK-Cu. Faster cellular uptake and superior skin penetration for accelerated results.
Our Buzz Button Anti-Aging Serum combines the natural muscle-relaxing power of 2% Buzz Button extract with a professional multi-peptide base. The peptide-rich foundation delivers hydration, barrier repair, and cellular regeneration while the Buzz Button extract targets expression lines — a synergistic dual-mechanism approach that outperforms single-ingredient formulas.
Everything you need to know about peptide and botanical anti-aging.
Expert insights on peptides, botanicals, anti-aging science, and the NOTOX revolution.
Deep dive into SNARE proteins, acetylcholine inhibition, and why Snap-8 is safer than botulinum toxin for wrinkle reduction...
Read Article →How spilanthol from Acmella Oleracea relaxes facial muscles, reduces expression lines, and why the beauty industry is paying attention...
Read Article →Week-by-week breakdown of visible changes, when results appear, and how to maximize your anti-aging peptide routine...
Read Article →